OPTIMIZATION OF THE SYNTHESIS METHOD FOR VITAMIN A NANOEMULSIONS

DOI: https://doi.org/10.6060/ivkkt.20246706.6966
Keywords: nanoemulsions, vitamin A, optimization, hydrodynamic radius, micelles

Abstract

The article presents the results of optimizing the procedure for the synthesis of vitamin A nanoemulsions. For the synthesis of nanoemulsions, vitamin A and Tween 80 were mixed, distilled water was added to the resulting mixture and mixed with a dispersant. To optimize the method for synthesizing vitamin A nanoemulsions, a multifactorial experiment was carried out, which included 4 input parameters. As input parameters, we considered the stirring speed, stirring time, the content of the dispersed phase, the content of fat-soluble vitamin A in the dispersed phase. The average hydrodynamic radius of vitamin A micelles was used as an output parameter. As a result of the studies, ternary surfaces of the dependence of the average hydrodynamic radius of vitamin A micelles on the parameters of nanoemulsion synthesis were obtained. It was found that all samples have a monomodal size distribution. The analysis of the data obtained made it possible to establish that the average hydrodynamic radius of vitamin A micelles is significantly affected by all the studied parameters. The optimal parameters for the synthesis of vitamin A nanoemulsions have been established: stirring speed (ν) - from 17000 to 22500 rpm, mixing time (τ) - from 180 to 270 s, content of the dispersed phase (ω (dispersed phase) - from 1 to 4%, the content of fat-soluble vitamin A in the dispersed phase (ω (vitamin A)) is from 50 to 70%. The nanoemulsion sample obtained with these parameters has an average hydrodynamic micelle radius of 62 ± 13 nm.

For citation:

Gvozdenko A.A., Blinov A.V., Golik A.B., Rekhman Z.A., Kolodkin M.A., Oblogin Y.A., Kuznetsov E.S. Optimization of the synthesis method for vitamin A nanoemulsions. ChemChemTech [Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.]. 2024. V. 67. N 6. P. 94-99. DOI: 10.6060/ivkkt.20246706.6966.

Author Biographies

Andrey V. Blinov, North Caucasian Federal University

Department of Physics and Technology of Nanostructures and Materials, Faculty of Physics and Technology, North Caucasus Federal University, 1 Pushkina str., Stavropol, Russia, 355017

 

Alexey B. Golik, North Caucasian Federal University

Department of Physics and Technology of Nanostructures and Materials, Faculty of Physics and Technology, North Caucasus Federal University, 1 Pushkina str., Stavropol, Russia, 355017

 

Zafar A. Rekhman, North Caucasian Federal University

Department of Physics and Technology of Nanostructures and Materials, Faculty of Physics and Technology, North Caucasus Federal University, 1 Pushkina str., Stavropol, Russia, 355017

 

Maxim A. Kolodkin, North Caucasian Federal University

Department of Physics and Technology of Nanostructures and Materials, Faculty of Physics and Technology, North Caucasus Federal University, 1 Pushkina str., Stavropol, Russia, 355017

 

Yaroslav A. Oblogin, North Caucasian Federal University

Department of Physics and Technology of Nanostructures and Materials, Faculty of Physics and Technology, North Caucasus Federal University, 1 Pushkina str., Stavropol, Russia, 355017

 

Egor S. Kuznetsov, Stavropol State Medical University

Faculty of Pediatrics, Stavropol State Medical University, st. Mira 310, Stavropol, Russian Federation

 

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Published
2024-05-04
How to Cite
Gvozdenko, A. A., Blinov, A. V., Golik, A. B., Rekhman, Z. A., Kolodkin, M. A., Oblogin, Y. A., & Kuznetsov, E. S. (2024). OPTIMIZATION OF THE SYNTHESIS METHOD FOR VITAMIN A NANOEMULSIONS. ChemChemTech, 67(6), 94-99. https://doi.org/10.6060/ivkkt.20246706.6966
Issue
Vol 67 No 6 (2024)
Section
CHEMICAL TECHNOLOGY (inorganic and organic substances. Theoretical fundamentals)

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