МЯГКИЕ ЛЕКАРСТВЕННЫЕ ФОРМЫ НА ОСНОВЕ РАСТВОРОВ ПЕКТИНА И ИОНОВ ДВУХВАЛЕНТНЫХ МЕТАЛЛОВ
Аннотация
Статья посвящена определению условий формирования мягких лекарственных форм на основе водных растворов пектина. С этой целью было проведено комплексное реологическое исследование растворов пектина в широком концентрационном диапазоне в присутствии ионов двухвалентных металлов – кальция, цинка и магния. Было обнаружено, что введение модифицирующих добавок сказывается на вязкости растворов пектина, пределе текучести и на пороге гелеобразования. Показано, что в присутствии ионов двухвалентных металлов – кальция, цинка и магния возрастает вязкость и предел текучести раствора пектина. Наиболее сильный прирост вязкости и предела текучести наблюдается для растворов с концентрацией 3 и 5 г/дл. Кроме того влияние ионов двухвалентных металлов на относительный прирост вязкости растворов пектина уменьшается в ряду Zn2+>Ca2+>Mg2+. Установлено, что в присутствии модифицирующей добавки происходит смещение порога гелеобразования. Показано, что закономерности влияния концентрации пектина и ионов двухвалентных металлов на реологические характеристики растворов пектина, находят свое отражение в процессах высвобождения лекарственных средств из жидких и мягких лекарственных форм. При изучении процесса высвобождения лекарств из полученных мягких лекарственных форм методом диализа через полупроницаемую мембрану установлено, что значения скоростей высвобождения лекарственного вещества при равной концентрации пектина в растворе однозначно тем меньше, чем больше содержание модифицирующей добавки. Кроме того, при одинаковом содержании модифицирующей добавки их влияние на скорость высвобождения лекарственного вещества уменьшается в ряду Zn2+>Ca2+>Mg2+. Наиболее сильное уменьшение скорости наблюдается для растворов пектина с концентрацией 3 и 5 г/дл.
Для цитирования:
Шуршина А.С., Афанасьева М.А., Лаздин Р.Ю., Кулиш Е.И. Мягкие лекарственные формы на основе растворов пектина и ионов двухвалентных металлов. Изв. вузов. Химия и хим. технология. 2026. Т. 69. Вып. 3. С. 87-95. DOI: 10.6060/ivkkt.20266903.6777.
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