МЕМБРАНЫ В БИОТЕХНОЛОГИИ: СОВРЕМЕННОЕ СОСТОЯНИЕ И ПЕРСПЕКТИВЫ
Аннотация
Мембранные процессы всегда являлись неотъемлемой частью биотехнологических процессов. Сегодня без них не обходится ни одно биотехнологическое производство: обратный осмос, ультрафильтрация, микрофильтрация, разделение газов, хроматография, первапорация и электродиализ – все эти процессы играют важную роль в тех или иных технологических решениях. Несмотря на то, что первые мембранные системы были заимствованы из технологий, которые разрабатывались для других промышленных применений, в течение последних 45 лет новые материалы и элементы создаются специально для нужд биотехнологической промышленности. Мембраны хорошо подходят для работы с биологическими молекулами: относительно низкие температуры и давления, отсутствие необходимости фазовых переходов и введения химических добавок минимизируют степень денатурации, дезактивации, и/или деградации биологических продуктов. В настоящее время мембранные технологии занимают лидирующие позиции в процессах стерилизующей фильтрации, осветления, культивирования клеточных культур, удаления вирусов, концентрирования и очистки белков. Все большее распространение получают процессы с применением мембранных биореакторов и мембранной хроматографии. В обзоре показаны возможности существующих разработок в мембранных технологиях, акцентируется внимание на используемых мембранных материалах и характеристиках мембранных систем, применяемых для коммерческого производства. Процессы мембранного разделения требуют более дорогостоящего оборудования по сравнению с традиционными процессами разделения, однако являются более энергоэффективными. По своей конструкции мембранные системы, как правило, компактны и имеют модульную архитектуру, благодаря которой появляется возможность использования одного и того же оборудования для решения различных задач. Имеются предпосылки того, что новые разработки в мембранных технологиях смогут удовлетворить растущие нужды биотехнологической отрасли в большей производительности и снижении стоимости производства.
Для цитирования:
Каталевский А.Д., Смирнов К.В., Смирнова Н.Н. Мембраны в биотехнологии: современное состояние и перспективы. Изв. вузов. Химия и хим. технология. 2025. Т. 68. Вып. 1. С. 6-22. DOI: 10.6060/ivkkt.20256801.7075.
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